May 2021 4 102 Report
Stem cells and gene therapy?

I know many say this is impossible without major surgery, but what I don't understand is that suppose if we changed the genes active in some bone to alter the size of it, then shouldn't the bone grow in that way once the body re-absorbs it again? Or if the bone was reduced and then stem cells were added with specific genes active (okay, I don't know too much about stem cells, and I assume that one would have to find a way to control the rate of their division), wouldn't this alter the way in which the bone grows?

So, for example... let's say that someone lost a toe/some complicated organ (perhaps one of their sexual organs, or a whole set), how would one go about replacing these organs if the original tissue is absent? Or alternatively, if the tissue is still there, and if one found a way to engineer some substance that switches on the genes of the tissue, then shouldn't the cell experience some type of metamorphosis?

Update:

Oh, specifically (again, my knowledge is limited on this subject) what if one were to reprogram an adult stem cell to change the bone size of a patient -- would they just inject the stem cell(s) into the target site from which the bone would "apparently" grow? So, ultimately could this be used to change the skeleton of a patients body? And furthermore, let's suppose that hypothetically someone lost an entire set of sexual organs somehow (or were a transsexual): would activating the appropriate genes in the stem cell and then placing it in the target location* result in the growth of new reproductive organs in the patient? The problem I see with this is how would the newly growing organ connect to nearby blood vessels? Or would it be cultivated in some bio-engineered environment?

*also, how would one know where to place the stem cells? From what I've learned, apparently they would automatically know how to interact with adjacent cells.


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